Street art? In Irvine? Apparently, now, the answer is yes. Local clothing manufacturer Tillys somehow persuaded the planning commission to allow them to commission Zio Ziegler (new Wikipedia article) to decorate one of their warehouses, right next to interstate 405, where approximately 240,000 daily drivers will see it.
You can't exactly stop on the freeway to take photos, but I found enough other more accessible vantage points to get a few shots: